Grants:
BBSRC Structural Biology and Design Initiative.
Awarded £141,536, ran from Nov. 1997 - Nov. 2000.
Prof. J.B.Jackson, Dr. S.A. White & Dr. K.J.Smith
The high resolution structure of domain III of proton-translocating nicotinamide nucleotide transhydrogenase.
morePublications:
Brear,K. Currey,J.D. Raines,S. & Smith,K.J.
(1988) Engineering in Medicine, 17, 4, 163-167.
Density and temperature effects on some of the mechanical properties of cancellous bone.
moreKeane,A.M. Smith.K.J.. & Trayer,I.P.
(1990) Biochem.Soc.Trans. 18, 264-266.
Short Report: The use of peptide mimetics and proton magnetic resonance to define actin binding sites on the myosin head.
moreTrayer,I.P., Keane,A.M., Murad,Z., Ruegg,J. & Smith,K.J.
(1991) Chapter in Peptides as Probes in Muscle Research, Springer-Verlag, p.57-68. Ed: Johann Caspar Ruegg
The use of peptide mimetics to define the actin binding sites on the head of the myosin molecule.
moreAlessi,D.R. Smith,K.J., & Trayer,I.P.
(1992) J.Muscle Res.Cell Motil., 13, 220.
Short Report: Location of an S1 binding site on an a-helical region of actin.
moreSmith,K.J.
(1993) PhD. Thesis, Dept. Biochemistry, University of Birmingham.
The Use of Peptide Mimentics to Investigate the interface between Actin and Myosin.
moreSmith,K.J., Eastwood,A.M. and Trayer,I.P.
(1993) J.Muscle Res. Cell Motil., 14, 272.
Short Report: Analysis of the weak binding site on actin.
moreJaseja,M., Smith,K.J., Lu,X., Williams,J.A., Trayer,H.R., Trayer,I.P. and Hyde,E.I.
(1993) Eur. J. Biochem., 218, 853-860.
1H-NMR studies and the secondary structure of the RGD-containing snake toxin, albolabrin.
moreSmith,K.J., Trayer,I.P. and Grand, R.J.A.
(1994) Biochemistry, 33, 20, 6063-6073.
Structure around the cleavage site in the thrombin receptor determined by NMR spectroscopy.
moreTrayer,I.P, Smith,K.J., Eastwood,A.M., and Trayer,H.R.
(1995) J.Musc.Res.Cell.Motil., 16, 450.
Short Report: Peptide mimetics as a probe of the contractile cycle.
moreSmith,K.J., Jaseja,M., Lu,X., Williams,J.A., Trayer,I.P., Hyde,E.I. and Trayer,I.P.
(1995) Intl. J. Peptide & Protein Research, 48, 3, 220-228.
3-Dimensional structure of the RGD-containing snake toxin Albolabrin in solution, based on 1H-NMR spectroscopy and simulated annealing calculations.
moreSmith,K.J.
, Scotland,G. Beattie,J. Trayer,I.P. and Houslay,M.D.(1996) J.Biol.Chem., 271, 28, 16703-16711.
Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H-NMR and identification of the membrane association domain using chimeric constructs.
moreI.P.Trayer and Smith,K.J.
(1997) Trends in Cell Biology, 7, 7, 259-263.
Review: Motoring down the highways of the cell.
moreJeeves,M. Smith,K.J. Quirk,P.G. Cotton,N.P.J. & Jackson,J.B.
(1999) J.Biomol.NMR 13, 305-306.
Assignment of the NADP(H)-binding Component (domain III) of the proton-translocating transhydrogenase from Rhodospirillum rubrum.
moreMolloy,D.P. Smith,K.J. Milner,A.E. Gallimore,P.H. & Grand,R.J.A.
(1999) J. Biol. Chem., 274, 6, 3503-3512.
The Structure of the Site on Adenovirus Early Region 1A Responsible for Binding to TATA-binding Protein Determined by NMR Spectroscopy.
moreTimson,D.J. Trayer,H.R. Smith,K.J. & Trayer,I.P.
(1999) J.Biol.Chem. 274(26), 18271-18277
Size and Charge Requirements for Kinetic Modulation and Actin Binding by A1-type Myosin Essential Light Chains.
moreQuirk,P.G. Smith,K.J.. Thomas, C. & Jackson,J.B.
(1999) Biochimica et Biophysica Acta (BBA)/Bioenergetics 1412(2), 139-148
The Mobile Loop Region of the NAD(H)-binding component (dI) of proton-translocating Nicotinamide Nucleotide Transhydrogenase from Rhodospirillum rubrum: Complete NMR assignment and effects of bound nucleotides.
morePhilip G. Quirk, Mark Jeeves, Nick P.J. Cotton, John K. Smith & Baz J. Jackson
(1999) FEBS Letters, 446, 1, 127-132.
Structural changes in the recombinant, NADP(H)-binding component of proton translocating transhydrogenase revealed by NMR spectroscopy
moreJeeves M.; Smith K.J.; Quirk P.G.; Cotton N.P.J.; Jackson J.B.
(2000) Biochimica et Biophysica Acta (BBA)/Bioenergetics, 1459(2), 248-257
Solution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from Rhodospirillum rubrum.
moreJ. W. Emsley,D. Merlet, K. J. Smith, and N. Suryaprakash
(2002) Journal of Magnetic Resonance 154, 303-310
Selective Detection of the Proton NMR Spectra of Molecules Containing Rare Spins at Natural Abundance in Liquid Crystalline Samples
moreRay P., Smith K.J., Parslow R.A., Dixon R., Hyde E.I.
(2002) Nucleic Acids Research 30(18), 3972-3980
Secondary structure and DNA binding by the C-terminal domain of the transcriptional activator NifA from Klebsiella pneumoniae
moreK John Smith, George S Baillie, Eva I Hyde, Xiang Li, Thomas M Houslay, Angela McCahill, Allan J Dunlop, Graeme B Bolger, Enno Klussmann, David R Adams, Miles D Houslay
(2007) Cellular Signalling 19(12), 2612-2624
(1)H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, betaarrestin and RACK1.
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