Publications - Dr. John Smith.
(High Resolution multidimensional Biological NMR).


Grants:

BBSRC Structural Biology and Design Initiative.

Awarded £141,536, ran from Nov. 1997 - Nov. 2000.

Prof. J.B.Jackson, Dr. S.A. White & Dr. K.J.Smith

The high resolution structure of domain III of proton-translocating nicotinamide nucleotide transhydrogenase.

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Publications:


Brear,K. Currey,J.D. Raines,S. & Smith,K.J.

(1988) Engineering in Medicine, 17, 4, 163-167.

Density and temperature effects on some of the mechanical properties of cancellous bone.

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Keane,A.M. Smith.K.J.. & Trayer,I.P.

(1990) Biochem.Soc.Trans. 18, 264-266.

Short Report: The use of peptide mimetics and proton magnetic resonance to define actin binding sites on the myosin head.

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Trayer,I.P., Keane,A.M., Murad,Z., Ruegg,J. & Smith,K.J.

(1991) Chapter in Peptides as Probes in Muscle Research, Springer-Verlag, p.57-68. Ed: Johann Caspar Ruegg

The use of peptide mimetics to define the actin binding sites on the head of the myosin molecule.

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Alessi,D.R. Smith,K.J., & Trayer,I.P.

(1992) J.Muscle Res.Cell Motil., 13, 220.

Short Report: Location of an S1 binding site on an a-helical region of actin.

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Smith,K.J.

(1993) PhD. Thesis, Dept. Biochemistry, University of Birmingham.

The Use of Peptide Mimentics to Investigate the interface between Actin and Myosin.

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Smith,K.J., Eastwood,A.M. and Trayer,I.P.

(1993) J.Muscle Res. Cell Motil., 14, 272.

Short Report: Analysis of the weak binding site on actin.

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Jaseja,M., Smith,K.J., Lu,X., Williams,J.A., Trayer,H.R., Trayer,I.P. and Hyde,E.I.

(1993) Eur. J. Biochem., 218, 853-860.

1H-NMR studies and the secondary structure of the RGD-containing snake toxin, albolabrin.

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Smith,K.J., Trayer,I.P. and Grand, R.J.A.

(1994) Biochemistry, 33, 20, 6063-6073.

Structure around the cleavage site in the thrombin receptor determined by NMR spectroscopy.

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Trayer,I.P, Smith,K.J., Eastwood,A.M., and Trayer,H.R.

(1995) J.Musc.Res.Cell.Motil., 16, 450.

Short Report: Peptide mimetics as a probe of the contractile cycle.

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Smith,K.J., Jaseja,M., Lu,X., Williams,J.A., Trayer,I.P., Hyde,E.I. and Trayer,I.P.

(1995) Intl. J. Peptide & Protein Research, 48, 3, 220-228.

3-Dimensional structure of the RGD-containing snake toxin Albolabrin in solution, based on 1H-NMR spectroscopy and simulated annealing calculations.

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Smith,K.J., Scotland,G. Beattie,J. Trayer,I.P. and Houslay,M.D.

(1996) J.Biol.Chem., 271, 28, 16703-16711.

Determination of the structure of the N-terminal splice region of the cyclic AMP-specific phosphodiesterase RD1 (RNPDE4A1) by 1H-NMR and identification of the membrane association domain using chimeric constructs.

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I.P.Trayer and Smith,K.J.

(1997) Trends in Cell Biology, 7, 7, 259-263.

Review: Motoring down the highways of the cell.

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Jeeves,M. Smith,K.J. Quirk,P.G. Cotton,N.P.J. & Jackson,J.B.

(1999) J.Biomol.NMR 13, 305-306.

Assignment of the NADP(H)-binding Component (domain III) of the proton-translocating transhydrogenase from Rhodospirillum rubrum.

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Molloy,D.P. Smith,K.J. Milner,A.E. Gallimore,P.H. & Grand,R.J.A.

(1999) J. Biol. Chem., 274, 6, 3503-3512.

The Structure of the Site on Adenovirus Early Region 1A Responsible for Binding to TATA-binding Protein Determined by NMR Spectroscopy.

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Timson,D.J. Trayer,H.R. Smith,K.J. & Trayer,I.P.

(1999) J.Biol.Chem. 274(26), 18271-18277

Size and Charge Requirements for Kinetic Modulation and Actin Binding by A1-type Myosin Essential Light Chains.

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Quirk,P.G. Smith,K.J.. Thomas, C. & Jackson,J.B.

(1999) Biochimica et Biophysica Acta (BBA)/Bioenergetics 1412(2), 139-148

The Mobile Loop Region of the NAD(H)-binding component (dI) of proton-translocating Nicotinamide Nucleotide Transhydrogenase from Rhodospirillum rubrum: Complete NMR assignment and effects of bound nucleotides.

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Philip G. Quirk, Mark Jeeves, Nick P.J. Cotton, John K. Smith & Baz J. Jackson

(1999) FEBS Letters, 446, 1, 127-132.

Structural changes in the recombinant, NADP(H)-binding component of proton translocating transhydrogenase revealed by NMR spectroscopy

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Jeeves M.; Smith K.J.; Quirk P.G.; Cotton N.P.J.; Jackson J.B.

(2000) Biochimica et Biophysica Acta (BBA)/Bioenergetics, 1459(2), 248-257

Solution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from Rhodospirillum rubrum.

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J. W. Emsley,D. Merlet, K. J. Smith, and N. Suryaprakash

(2002) Journal of Magnetic Resonance 154, 303-310

Selective Detection of the Proton NMR Spectra of Molecules Containing Rare Spins at Natural Abundance in Liquid Crystalline Samples

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Ray P., Smith K.J., Parslow R.A., Dixon R., Hyde E.I.

(2002) Nucleic Acids Research 30(18), 3972-3980

Secondary structure and DNA binding by the C-terminal domain of the transcriptional activator NifA from Klebsiella pneumoniae

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K John Smith, George S Baillie, Eva I Hyde, Xiang Li, Thomas M Houslay, Angela McCahill, Allan J Dunlop, Graeme B Bolger, Enno Klussmann, David R Adams, Miles D Houslay

(2007) Cellular Signalling 19(12), 2612-2624

(1)H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, betaarrestin and RACK1.

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